Web Reference: Nov 27, 2025 · PR3 is an abbreviation for Proteinase 3, an enzyme primarily stored within the azurophilic granules of these neutrophils. Proteinase 3 is a serine protease whose normal function involves breaking down proteins and degrading foreign materials at sites of inflammation. A consensus guideline published in 2017 recommends that patients with possible GPA or MPA be tested for PR3-ANCA and MPO-ANCA using antigen-specific immunoassays. Anti-PR3 is a blood test that measures antibodies directed against proteinase 3, an enzyme found inside certain white blood cells called neutrophils.
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